Design, manufacture and testing of rabbit implantation structures for preclinical examinations

Anotace: The aim of this study was to develop a methodology of preclinical animal testing in case studies for implants with PEEK material and its derivatives with possible use for other materials. In the theoretical part, the study deals with the analysis of the current situation in the area of preclinical animal testing, especially in the field of implantology. Based on this analysis, the test implant structures were prepared at the workplace, which were subsequently inserted into appropriate rabbit individuals by surgical intervention in case studies. These case studies serve to create a comprehensive test methodology for animal preclinical tests within a statistically relevant animal sample for the needs of subsequent clinical testing and certification of the biomaterial used.