Inhibitory effects of sterculia lychnophora hance ethanol extracts on biofilm formation and virulence factors of pseudomonas aeruginosa

Anotace: This study aimed to explore the inhibitory effects of dried fruit ethanol extracts of Sterculia lychnophora Hance (SLHe), a traditional medicinal plant known as Pangdahai, on biofilm formation and virulence factors of Pseudomonas aeruginosa. Screening of bioactive compounds extracted from Sterculia lychnophora revealed a strong binding affinity to anthranilate-CoA ligase (PqsA), which regulates genes involved in pyocyanin production and biofilm formation. The experimental investigation confirmed the inhibitory effects of SLHe on biofilm formation and its ability to disrupt existing biofilms. Additionally, SLHe exhibited reductions in pyocyanin production and protease activity of Pseudomonas aeruginosa. These findings indicate the therapeutic potential of SLHe as a natural alternative for treating bacterial infections, particularly those associated with bacterial biofilm formations.