Chemical constituents of aspergillus carbonarius isolated from marine sponge aaptos suberitoides

Anotace: An endophytic fungus identified as Aspergillus carbonarius was obtained from from sea sponge Aaptos suberitioides. Phytochemical study of fungal A. carbonarius led to the isolation of four compounds (1-4) of which compound 1 was a new isocoumarin derivative, (R)-6-hydroxy-3-(1-hydroxypropan-2-yl)-8-methoxyisocoumarin. The others (compounds 2-4) were the known compounds. Isolation of these compounds was performed using vacuum liquid dan column chromatography. The structure elucidation and identification of these compounds were conducted with the help of NMR and HR-ESI-MS spectroscopic data. All isolated compounds (1-4) were tested for their antibacterial activity against five bacterial strains and displayed inactive activity against all tested microorganisms.